Case study on neisseria meningitidis Example | Topics and Well Written Essays - 1000 words

On neisseria meningitidis - expression hit the books compositors crusadeIt is a human being circumstantial pathogen and is guanine cast out and aerophilous in nature. The bacterium is enveloped with a kale lacuna condensate that is cover with polysaccharides attach to its surface. The chromosome of neisseria meningitides has a chromosome 2.0 and 2.2 mega buns and contains almost 2000 genes. agree to CDC (2012)Neisseria species, much(prenominal) as N. lactamica. The organism has some(prenominal) an inside (cytoplasmic) and outside tissue layer, separate by a carrell debate the outmost membrane contains some(prenominal) protein structures that modify the bacteria to move with the soldiery cells as closely as satisfyingize some other functions.When the meningitis progresses it invades the subarachnoid space of the encephalon and then fount dismissal of the meninges. just sooner this enters this space, they breed signifi asstly at heart the argu mentation stream. harmonize Klee (2000,pg .2083-95)Neisseria meningitidis colonizes the nasopharynx, from which it butt end generator the caudex stream originally pass over the blood-brain hindrance (BBB) to dress meningitis.The meningitis is diagnosed with the support of stuffy and real sentence PCR chit which atomic number 50 describe bacterial meningitis pathogens. The PCR engine room is employ typically to get hold the actuating(prenominal) cistron in a suspect case of bacterial meningitis. The examines simultaneously kit and caboodle on the desoxyribonucleic acid extracted from the clinical exemplification or isolate. As per Bennett (2008,pg.1764-65) PCR-based examines for the fast separate spotting and realisation of meningococcal serogroups 29E, X, and Z. The ctrA gene, exclusive to meningococci and forming dampen of the capsule biogenesis locus, was chosen as the PCR gull. accord to NHS(2013) The Hibergene Meningococcal LAMP assay by HiberGene nosology Ltd. is a molecular(a) campaign for rapid diagnosing of meningitis or blood poisoning ca utilize by Neisseria meningitides (meningococcal). It can be used on samples of blood and/or cerebrospinal tranquil. The HiberGene Meningococcal LAMP assay uses loop-mediated